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MC180295

SKU: orb1301717

Description

MC180295

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2237942-08-2
MW358.41
Purity99.84%
FormulaC17H18N4O3S
SMILESNc1nc(N[C@H]2C[C@@H]3CC[C@H]2C3)sc1C(=O)c1ccccc1[N+]([O-])=O
TargetCDK
SolubilityDMSO:70 mg/mL (195.31 mM)

Bioactivity

Target IC50
CDK7-CyclinH-MAT1:555 nM|CDK9-CyclinT1:5 nM (cell free)|CDK2-CyclinA:233 nM|CDK1-CyclinB:138 nM (cell free)|CDK3-CyclinE:399 nM|CDK5-p25:186 nM (cell free)|CDK2-CyclinE:367 nM|CDK5-p35:159 nM (cell free)|CDK4-CyclinD:112 nM (cell free)|CDK6-CyclinD1:712 nM
In Vivo
MC180295 (20 mg/kg, i.p., qod) demonstrates significant anti-tumor activity in mice with SW48 cells without inhibiting human T cell growth in vivo.
In Vitro
MC180295 is a potent, selective CDK9-Cyclin T1 inhibitor with an IC50 of 5 nM, displaying at least 22-fold selectivity over other CDKs, including CDK1-Cyclin B (IC50, 138 nM), CDK2-Cyclin A (IC50, 233 nM), CDK2-Cyclin E (IC50, 367 nM), CDK3-Cyclin E (IC50, 399 nM), CDK4-Cyclin D (IC50, 112 nM), CDK5-P35 (IC50, 159 nM), and CDK5-P25 (IC50, 186 nM). MC180295 (0.1 μM) demonstrates broad anti-cancer activity in vitro.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Cyclin dependent kinase, CDK9/cyclin T1, CDK, (rel)-MC 180295, (rel)-MC180295, (rel)-MC-180295, MC 180295, MC180295, MC-180295, Inhibitor, inhibit

Similar Products

  • MC180295 [orb1225612]

    >98% (HPLC)

    2237942-08-2

    358.416

    C17H18N4O3S

    5 mg, 2 mg, 10 mg, 25 mg, 1 g, 500 mg, 200 mg, 100 mg, 50 mg
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Key Properties

No computed properties available.

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Protocol Information

MC180295 (orb1301717)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 180.00
1 ml x 10 mM (in DMSO)
$ 190.00
10 mg
$ 240.00
25 mg
$ 380.00
50 mg
$ 520.00
100 mg
$ 720.00
200 mg
$ 930.00
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