Mdivi

SKU: orb1307150

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Description

Mdivi-1 is a selective inhibitor of mitochondrial fission protein DRP1 and Dynamin I, with IC50 values in the 1-10 μM range. It is widely used in both in vitro and in vivo research to study mitochondrial dynamics, mitophagy, and their roles in neurodegenerative and cardiovascular diseases.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	338967-87-6
MW	353.23
Purity	>98%
Formula	C₁₅H₁₀Cl₂N₂O₂S
SMILES	O=C1N(C(=S)NC=2C1=CC=CC2)C3=CC(OC)=C(Cl)C=C3Cl
Target	GTPase
Solubility	Soluble in DMSO (up to 25 mg/ml).

Bioactivity

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Target IC50	MDA-MB-231 cells:55.93 ± 1.92 μM\|POP92:15 µM\|Dnm1 GTPase:1 μM-10 μM
In Vivo	Mdivi-1 inhibits the ATPase activity and self-assembly of Dnm1 by inducing a conformational change (IC50<10 μM). It effectively suppresses C8-Bid and STS-induced mitochondrial outer membrane permeabilization (MOMP) in HeLa cells and extracellular mouse liver mitochondria. Mdivi-1 blocks the divisionof Dynamin-related GTPases, yeast Dnm1, and human Drp1, facilitating efficient and reversible mitochondrial fusion into a net-like structure. Intracellularly, it prevents apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 represents a potential therapeutic class for treating stroke, myocardial infarction, and neurodegenerative diseases. Read more...
In Vitro	In the ganglion cell layer (GCL), Mdivi-1 exhibits strong immunoreactivity. Twelve hours following ischemic induction, Mdivi-1 significantly increases protein expression within the GCL. It notably reduces the expression of GFAP protein without altering Drp1 protein expression. In the normal murine retina, Mdivi-1 primarily localizes to the inner plexiform layer, ganglion cell layer, outer plexiform layer, and inner nuclear layer. Early in the development of the ischemic murine retina, there is a marked increase in the protein expression of Mdivi-1 and glial fibrillary acidic protein (GFAP). Mdivi-1 inhibits apoptosis in the ischemic retina and significantly increases the survival rate of retinal ganglion cells (RGC) two weeks post-ischemia. Read more...
Cell Research	Mdivi-1 is dissolved in DMSO. YPGlycerol plates are topped with 10 mL YPGlycerol containing 1% low melt agar and 75 μM mdivi-1, and cells are spotted 12 hours later using a 48 well pinning device. After pinning cells, plates are incubated at 24°C or 37°C and imaged using an Eagle Eye II imaging system. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Mdivi-1

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Compound Identifiers

PubChem CID

3825829 ↗

Key Properties

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No computed properties available.

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Mdivi (orb1307150)

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CAS Number:	73326-98-4
MW:	248.24
Formula:	C₁₅H₈N₂O₂

Purity:	>98% (HPLC)
CAS Number:	338967-87-6
MW:	353.22
Formula:	C₁₅H₁₀Cl₂N₂O₂S

Mdivi

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Mdivi (orb1307150)

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