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Mdivi-1

SKU: orb1307150

Description

Mdivi-1 is a selective inhibitor of mitochondrial fission protein DRP1 and Dynamin I, with IC50 values in the 1-10 μM range. It is widely used in both in vitro and in vivo research to study mitochondrial dynamics, mitophagy, and their roles in neurodegenerative and cardiovascular diseases.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Mdivi-1

Key Properties

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CAS Number338967-87-6
MW353.22
Purity99.23% (May vary between batches)
FormulaC15H10Cl2N2O2S
SMILESO=C1N(C(=S)NC=2C1=CC=CC2)C3=CC(OC)=C(Cl)C=C3Cl
TargetAutophagy,Mitophagy,Apoptosis,Dynamin
SolubilityDMSO:50 mg/mL (141.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.54 mg/mL (10.02 mM)

Bioactivity

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Target IC50
MDA-MB-231 cells:55.93 ± 1.92 μM|POP92:15 µM|Dnm1 GTPase:1 μM-10 μM
In Vivo
Mdivi-1 inhibits the ATPase activity and self-assembly of Dnm1 by inducing a conformational change (IC50<10 μM). It effectively suppresses C8-Bid and STS-induced mitochondrial outer membrane permeabilization (MOMP) in HeLa cells and extracellular mouse liver mitochondria. Mdivi-1 blocks the divisionof Dynamin-related GTPases, yeast Dnm1, and human Drp1, facilitating efficient and reversible mitochondrial fusion into a net-like structure. Intracellularly, it prevents apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 represents a potential therapeutic class for treating stroke, myocardial infarction, and neurodegenerative diseases.
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In Vitro
In the ganglion cell layer (GCL), Mdivi-1 exhibits strong immunoreactivity. Twelve hours following ischemic induction, Mdivi-1 significantly increases protein expression within the GCL. It notably reduces the expression of GFAP protein without altering Drp1 protein expression. In the normal murine retina, Mdivi-1 primarily localizes to the inner plexiform layer, ganglion cell layer, outer plexiform layer, and inner nuclear layer. Early in the development of the ischemic murine retina, there is a marked increase in the protein expression of Mdivi-1 and glial fibrillary acidic protein (GFAP). Mdivi-1 inhibits apoptosis in the ischemic retina and significantly increases the survival rate of retinal ganglion cells (RGC) two weeks post-ischemia.
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Cell Research
Mdivi-1 is dissolved in DMSO. YPGlycerol plates are topped with 10 mL YPGlycerol containing 1% low melt agar and 75 μM mdivi-1, and cells are spotted 12 hours later using a 48 well pinning device. After pinning cells, plates are incubated at 24°C or 37°C and imaged using an Eagle Eye II imaging system.
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Storage & Handling

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Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Mdivi 1, Mdivi1, Mdivi-1, inhibit, Inhibitor, Mitophagy, Mitochondrial division inhibitor 1, Mitochondrial division inhibitor1, Mitochondrial division inhibitor-1, Mitochondrial Autophagy, Dynamin, Dnm1 GTPase, Autophagy, Apoptosis

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
3825829 ↗

Key Properties

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No computed properties available.

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Mdivi-1 (orb1307150)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 100.00
25 mg
$ 140.00
50 mg
$ 200.00
100 mg
$ 280.00
200 mg
$ 400.00
500 mg
$ 630.00
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