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ME-3221

SKU: orb1699978

Description

ME-3221 is a selective angiotensin II type 1 (AT1) receptor antagonist. It has demonstrated efficacy in reducing hypertensive complications in preclinical studies using aged stroke-prone spontaneously hypertensive rats (SHRSP). This compound is a valuable research tool for investigating the renin-angiotensin system in cardiovascular and renal disease models, both in vivo and in vitro.
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Research Area

Metabolism Research

Images & Validation

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ME-3221

Key Properties

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CAS Number139958-16-0
MW387.43
Purity>99.99% (May vary between batches)
FormulaC22H21N5O2
SMILESN1=NNC(=N1)C=2C=CC=CC2C=3C=CC(=CC3)COC=4C=C(N=C(C4OC)C)C
TargetRAAS,Angiotensin-converting Enzyme (ACE)

Bioactivity

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In Vivo
ME3221 inhibited the pressor response to angiotensin II in rats at doses of 0.3-1.0 mg/kg. Higher doses of ME3221 (3-10 mg/kg) were required to achieve the same inhibitory potency in dogs.The antagonistic potency of ME3221 against angiotensin II-induced contraction in rabbit aorta (pA2 = 8.82) was approximately fivefold higher than in canine aorta (pA2 = 8.18).;Long-term (8 months) oral administration of ME3221 (10 mg/kg/d) to aged (32 weeks) stroke-prone hypertensive rats (SHRSP) suppressed mortality and hypertensive complications observed in control SHRSP: stroke (hemorrhage, spongiosis and flaccidity in the cerebral cortex), increased proteinuria, total N-acetyl-β-D-glucosaminidase activity and cardiac hypertrophy and pleural effusion. ；SHRSP were orally administered ME3221 (3 and 10 mg/kg per day) from 6 to 20 weeks, and ME3221 inhibited to a considerable extent the elevation of SBP in salt-containing SHRSP, increased survival to >90%, and reduced hypertensive complications such as stroke (moderate), renal injury (increased proteinuria and total N-acetyl-β-D-glucosaminidase activity), and heart failure (cardiac hypertrophy and pleural effusion).
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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AT1 receptor, ME3221, ME-3221, ME 3221
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Compound Identifiers

PubChem CID
178553 ↗

Key Properties

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No computed properties available.

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ME-3221 (orb1699978)

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1 mg
$ 220.00
5 mg
$ 480.00
10 mg
$ 640.00
25 mg
$ 960.00
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