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Mezigdomide

SKU: orb1309864

Description

Mezigdomide (CC-92480) is a novel molecular glue-type CELMoD that potently and selectively modulates the cereblon E3 ubiquitin ligase. It demonstrates significant anti-myeloma activity in preclinical studies, supporting its investigation in both in vitro and in vivo research for multiple myeloma and related hematological malignancies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2259648-80-9
MW567.61
Purity99.68% (May vary between batches)
FormulaC32H30FN5O4
SMILESO(CC1=CC=C(CN2CCN(CC2)C3=C(F)C=C(C#N)C=C3)C=C1)C4=C5C(C(=O)N(C5)[C@@H]6C(=O)NC(=O)CC6)=CC=C4
TargetApoptosis,Molecular Glues,E1/E2/E3 Enzyme
SolubilityDMSO:5 mg/mL (8.81 mM)

Bioactivity

In Vivo
Mezigdomide (1 mg/kg) reduced tumor volume by 75% when administered orally to tumor-bearing mice for 21 days.
In Vitro
Mezigdomide (CC-92480)-induced loss of Aiolos and Ikaros in PBMC cultures resulted in T cell activation and increased IL-2 and IFN-γ production; Mezigdomide (CC-92480) induced apoptosis as a single agent and exhibited significant synergy with NSC 34521; Mezigdomide (CC-92480) was effective against CC-4047, CC-5013, and CC-220 resistant cell lines.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E2 Enzyme, E2 conjugating enzyme, E1Enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1 activating enzyme, CC 92480, CC92480, CC-92480, Apoptosis, inhibit, MolecularGlues, Molecular Glues, Mezigdomide, Inhibitor, E3 ligating enzyme, E3 Enzyme, E2Enzyme, E3Enzyme, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase
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Key Properties

No computed properties available.

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Mezigdomide (orb1309864)

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Available Sizes

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1 mg
$ 160.00
5 mg
$ 330.00
10 mg
$ 500.00
25 mg
$ 800.00
50 mg
$ 1,100.00
100 mg
$ 1,470.00
500 mg
$ 2,900.00
DispatchUsually dispatched within 3-5 working days
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