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(-)-MK 801 Maleate

SKU: orb1222805

Description

MK-801 is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

Images & Validation

Key Properties

CAS Number121917-57-5
MW337.37
Purity>98% (HPLC)
FormulaC20H19NO4
SMILESO=C(O)/C=C\C(=O)O.C[C@]42N[C@@H](Cc1ccccc12)c3ccccc34
TargetNMDA Receptor
SolubilityDMSO : ≥ 30 mg/mL; 88.92 mM

Bioactivity

In Vivo
(-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model. Animal model: Male adult C57BL/6 mice (20-25g; aged 8 weeks) with social defeat stress model. Dosage: 0.1 mg/kg. Administration: Intraperitoneal injection. Result: Induced rapid antidepressant effects in the social defeat stress model.
In Vitro
(-)-Dizocilpine maleate ((-)-MK-801 maleate) significantly inhibited the uptake of all three (norepinephrine, dopamine and serotonin) monoamine transporters in a dose-dependent manner in HEK cells. The Ki values of (-)-Dizocilpine on the norepinephrine, dopamine and serotonin transporters are 3.7 μM, 40 μM and 47 μM, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(-)-MK 801 (Maleate)

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(-)-MK 801 Maleate (orb1222805)

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