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ML-SA1

SKU: orb1305751

Description

ML-SA1

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number332382-54-4
MW362.42
Purity99.34%
FormulaC22H22N2O3
SMILESCC1CC(C)(C)N(C(=O)CN2C(=O)C3=CC=CC=C3C2=O)C2=C1C=CC=C2
TargetAnti-infection,TRP/TRPV Channel
SolubilityDMSO:17 mg/mL (46.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.52 mM)

Bioactivity

Target IC50
DENV-2:8.3 μM (IC50)|ZIKV:52.99 μM (IC50)
In Vitro
ML-SA1 (25 μM; 0~14 hours; A549 cells) potentially affects the entry of DENV2 into host cells. ML-SA1 (0~200 μM; A549 cells) shows no cytotoxicity at concentrations up to 200 μM. It significantly suppresses DENV2 RNA levels with an IC50 of 8.93 μM. ML-SA1 also reduces ZIKV RNA and protein levels in a dose-dependent manner, with an IC50 of 52.99 μM against ZIKV RNA. As an activator of TRPMLs, ML-SA1 is a potent inhibitor of DENV2 and ZIKV in vitro, promoting lysosomal acidification and protease activity to inhibit viral infection, and can induce autophagy in Huh7 or A549 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Dengue, acidification, antiviral, autophagy, broad-spectrum, lysosomal, ML SA1, MLSA1, ML-SA1, ML-SA-1, Mucolipin synthetic agonist 1, inhibit, Inhibitor, selective, protease, Zika, virus, TRP Channel, Transient receptor potential channels, TRPV Channel, TRPML, TRPChannel, TRPVChannel

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    332382-54-4

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Quality Guarantee

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Key Properties

No computed properties available.

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ML-SA1 (orb1305751)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 200.00
50 mg
$ 300.00
100 mg
$ 430.00
200 mg
$ 620.00
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