MOCOS (N) Antibody, Rabbit Polyclonal

SKU: orb67220

Description

Rabbit polyclonal to MOCOS.Molybdenum cofactor sulfurase (MOCOS) belongs to the class-V pyridoxal-phosphate-dependentaminotransferase family. It sulfurates the molybdenum cofactor. Sulfation of molybdenum is essentialfor xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenumcofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain isable to reduce N-hydroxylated prodrugs, such as benzamidoxime. Defects in MOCOS are the causeof xanthinuria type 2 (XU2). Patients suffering XU2 cannot metabolize allopurinol into oxypurinol dueto dual deficiency of xanthine dehydrogenase and aldehyde oxidase.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution Range	WB:1:500-1:1000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human MOCOS
Molecular Weight	98
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti-MOCOS antibody,anti-Molybdenum cofactor sulfurase antibody,anti-MCS antibody,anti-MOS antibody,anti-MoCo sulfurase antibody,anti-hMCS antibody

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Western blot analysis of total cell extracts from human HepG2 using MOCOS antibody

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UniProt

Q96EN8

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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