Monensin sodium salt

SKU: orb1309997

Description

Monensin sodium salt, a polyether antibiotic derived from Streptomyces cinnamonensis, is a research tool for studying intracellular transport. It potently induces multivesicular body (MVB) enlargement and modulates exosome biogenesis and secretion, making it valuable for in vitro investigations of extracellular vesicle biology and cellular communication pathways.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	22373-78-0
MW	692.85
Purity	98.90% (May vary between batches)
Formula	C₃₆H₆₁NaO₁₁
SMILES	[Na+].CC[C@]1(CC[C@@H](O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@@H]1O[C@H](C[C@@H]1C)[C@H]1O[C@@](O)(CO)[C@H](C)C[C@@H]1C
Target	Parasite,Antibacterial,Antifungal,Antibiotic,Sodium Channel,Apoptosis,Wnt/beta-catenin
Solubility	10% EtOH+90% Corn Oil:1 mg/mL (1.44 mM);Ethanol:12.5 mg/mL (18.04 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vivo

LD50: Mice 335 mg/kg (i.g.) ; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.).

In Vitro

Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bacterial, Antibiotic, Antibacterial, inhibit, Monensin, Monensin A, Monensin A sodium, Monensin A sodium salt, Monensin sodium, Monensin sodium salt, Na+/H+ Exchanger (NHE), Inhibitor, Sodium Channel, Sodium/hydrogen Exchanger, SodiumChannel, Sodium-hydrogen Exchanger, Sodium Monensin

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Compound Identifiers

PubChem CID

23667299 ↗

Key Properties

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No computed properties available.

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