Monensin sodium salt

SKU: orb1309997

Description

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	22373-78-0
MW	692.85
Purity	98.00%
Formula	C₃₆H₆₁NaO₁₁
SMILES	[Na+].CC[C@]1(CC[C@@H](O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@@H]1O[C@H](C[C@@H]1C)[C@H]1O[C@@](O)(CO)[C@H](C)C[C@@H]1C
Target	Wnt/beta-catenin,Antibacterial,Antifungal,Parasite,Antibiotic,Sodium Channel,Apoptosis
Solubility	10% EtOH+90% Corn Oil:1 mg/mL (1.44 mM);Ethanol:12.5 mg/mL (18.04 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vivo

LD50: Mice 335 mg/kg (i.g.) ; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.).

In Vitro

Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and Other biological activities. the antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Bacterial, Antibiotic, Antibacterial, inhibit, Monensin, Monensin A, Monensin A sodium, Monensin A sodium salt, Monensin sodium, Monensin sodium salt, Na+/H+ Exchanger (NHE), Inhibitor, Sodium Channel, Sodium/hydrogen Exchanger, SodiumChannel, Sodium-hydrogen Exchanger, Sodium Monensin

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Compound Identifiers

PubChem CID

23667299 ↗

Key Properties

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No computed properties available.

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