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Mosnodenvir

SKU: orb2944173

Description

Mosnodenvir (JNJ-1802) is a pan-DENV inhibitor effective against all four serotypes of dengue viruses, with the advantage of being highly potent and orally bioavailable, and blocks viral replication by inhibiting the formation of the complex between NS3 and NS4B.

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2043343-94-6
MW582.98
Purity99.72%
FormulaC26H22ClF3N2O6S
SMILESC(C(NC1=CC(S(C)(=O)=O)=CC(OC)=C1)C2=C(OC)C=C(Cl)C=C2)(=O)C=3C=4C(NC3)=CC=C(OC(F)(F)F)C4
TargetVirus Protease,Antiviral

Bioactivity

Target IC50
SARS-CoV-2 BA.5:0.27 μM (EC₅₀)|SARS-CoV-2 XBB:0.43 μM (EC₅₀)
In Vivo
In hACE2 transgenic mice, Mosnodenvir (200 mg/kg, i.p., daily × 5 days) reduced lung viral titers by >99% and alleviated lung damage, with good oral bioavailability (>80%).
In Vitro
Mosnodenvir inhibited SARS-CoV-2 BA.5 and XBB in Vero E6 cells with EC₅₀ values of 0.27 μM and 0.43 μM, respectively, and showed broad-spectrum antiviral activity in other cell lines.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JNJ 64281802, JNJ-1802, (S)-Mosnodenvir

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    C26H22ClF3N2O6S

    50 mg, 100 mg, 25 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Mosnodenvir (orb2944173)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 200.00
5 mg
$ 370.00
1 ml x 10 mM (in DMSO)
$ 460.00
10 mg
$ 560.00
25 mg
$ 920.00
50 mg
$ 1,350.00
100 mg
$ 2,000.00
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