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MRS4719

SKU: orb1744157

Description

MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can decrease infarct volume and brain atrophy in an ischemic stroke model. Additionally, MRS4719 mitigates ATP-induced calcium influx in primary human monocyte-derived macrophages, making it a valuable tool for researching ischemic stroke.

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Key Properties

CAS Number2840581-32-8
MW504.6
FormulaC26H13N5O3S.C6H15N
SMILESO=C1NC=2C=3C=CC=CC3C=CC2N(C4=CC=NC(=C4)C5=NOC(=S)N5)C(=O)C1.N(CC)(CC)CC
TargetP2X Receptor,Others

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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MRS4719 (orb1744157)

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