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Mulberroside A

SKU: orb1222922

Description

Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of melanogenesis. Mulberroside A has anti-inflammatory antiapoptotic effects. by decreasing the expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and inhibiting the activation of NALP3, caspase-1, and nuclear factor-κB and the phosphorylation of extracellular signal-regulated protein kinases, the c-Jun N-terminal kinase, and p38.

Images & Validation

Key Properties

CAS Number102841-42-9
MW568.52
Purity>98% (HPLC)
FormulaC26H32O14
SMILESC1=CC(=C(C=C1OC2C(C(C(C(O2)CO)O)O)O)O)C=CC3=CC(=CC(=C3)OC4C(C(C(C(O4)CO)O)O)O)O
TargetOthers
SolubilityDMSO : ≥ 40 mg/mL; 70.36 mM

Bioactivity

In Vivo
Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic micem. Animal model: Male Kun-Ming mice (20±2 g). Dosage: 5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight. Administration: Orally initiated at 9: 00 a. m. Result: 10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Mulberroside A | Mulberroside-A

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Mulberroside A (orb1222922)

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