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Mutant IDH1-IN-2

SKU: orb1309381

Description

Mutant IDH1-IN-2 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1, exhibiting IC50 values below 22 nM in biochemical assays. This small molecule is a valuable research tool for investigating oncogenic IDH1 function in cancers like glioma and AML, supporting both in vitro and in vivo mechanistic studies.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1429176-69-1
MW459.53
Purity99.88% (May vary between batches)
FormulaC24H31F2N5O2
SMILESCC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCC(F)(F)CC3)cc2)n1
TargetIsocitrate Dehydrogenase (IDH)
SolubilityDMSO:9 mg/mL (19.59 mM);10% DMSO+90% Corn Oil:0.5 mg/mL (1.09 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

Target IC50
IDH:16.6 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IsocitrateDehydrogenase(IDH), IsocitrateDehydrogenase, Isocitrate Dehydrogenase (IDH), Isocitrate Dehydrogenase, Mutant IDH1IN2, Mutant IDH-1-IN-2, Mutant IDH1-IN-2, Mutant IDH1 IN 2, inhibit, Inhibitor, IDH
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Mutant IDH1-IN-2 (orb1309381)

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Step 1: Enter information below

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 190.00
5 mg
$ 190.00
10 mg
$ 290.00
25 mg
$ 460.00
50 mg
$ 640.00
100 mg
$ 840.00
200 mg
$ 1,110.00
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