N-Acetyl lysyltyrosylcysteine amide

SKU: orb1692343

Description

N-Acetyl lysyltyrosylcysteine amide is a potent, specific, and reversible tripeptide inhibitor of myeloperoxidase (MPO). It attenuates MPO-mediated oxidative damage, such as HOCl production and LDL oxidation, and has demonstrated neuroprotective effects in vivo stroke models. This inhibitor is a valuable research tool for studying inflammatory conditions like bronchial dysplasia and neurodegenerative diseases.

Research Area

Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	1287585-40-3
MW	453.56
Purity	99.02% (May vary between batches)
Formula	C₂₀H₃₁N₅O₅S
SMILES	[C@@H](CC1=CC=C(O)C=C1)(NC([C@H](CCCCN)NC(C)=O)=O)C(N[C@H](C(N)=O)CS)=O
Target	Glutathione Peroxidase
Solubility	DMSO:55 mg/mL (121.26 mM)

Bioactivity

−

In Vivo

N-Acetyl lysyltyrosylcysteine amide (KYC) (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) significantly reduces neurological severity scores and infarct size in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days; C57BL/6J mice) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.

Storage & Handling

−

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

N Acetyl lysyltyrosylcysteine amide, MPO, NAcetyl lysyltyrosylcysteine amide, N-Acetyl lysyltyrosylcysteine Amide, Glutathione Peroxidase, GlutathionePeroxidase

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

51352312 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols