N-(p-Coumaroyl) serotonin

SKU: orb1297274

Description

N-(p-Coumaroyl) Serotonin, a safflower seed polyphenol, is a research compound studied for its antioxidant, cardioprotective, and anti-atherosclerotic properties. It is utilized in cardiovascular research, particularly in models investigating vascular distensibility and aortic wall function in vivo.

Research Area

Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	68573-24-0
MW	322.36
Purity	98.89%
Formula	C₁₉H₁₈N₂O₃
SMILES	Oc1ccc(\C=C\C(=O)NCCc2c[nH]c3ccc(O)cc23)cc1
Target	PDGFR,Caspase,ERK
Solubility	DMSO:66.67 mg/mL (206.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.2 mM)

Bioactivity

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In Vitro

As reactive oxygen species (ROS) are implicated in the signaling of lipopolysaccharide (LPS), we examined whether CS has a suppressive effect on inflammatory cytokine generation from human monocytes in vitro. CS at 50-200 microM reduced tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6 activities in the culture supernatants from LPS-stimulated human blood monocytes without cytotoxicity. ELISA assay revealed that the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 was inhibited by CS. Northern blot analysis showed that LPS-induced expression of these cytokine mRNA in monocytes was suppressed by CS. NF-kappaB activation was also inhibited by CS

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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dysfunction, distensibility, atherosclerosis, aortic wall, anti-inflammatory, N (p Coumaroyl) serotonin, inhibit, N(pCoumaroyl) serotonin, N-(p-Coumaroyl) serotonin, NF-κB, PDGFR, Platelet-derived growth factor receptor, Inhibitor, VSMC, TNF-α, ROS

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Compound Identifiers

PubChem CID

5458879 ↗

Key Properties

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No computed properties available.

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