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N-piperidine Ibrutinib hydrochloride

SKU: orb2901779

Description

N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

Images & Validation

Key Properties

CAS Number2231747-18-3
MW422.91
Purity>98% (HPLC)
FormulaC22H23ClN6O
SMILESCl.Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCNCC1
TargetBTK
SolubilityIn Vitro: DMSO : 100 mg/mL (236.46 mM; Ultrasonic ) H2O : 50 mg/mL (118.23 mM; Ultrasonic)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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N-piperidine Ibrutinib hydrochloride (orb2901779)

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Available Sizes

Select a size below

500 mg
2 mg
$ 120.00
5 mg
$ 160.00
10 mg
$ 240.00
25 mg
$ 430.00
50 mg
$ 620.00
100 mg
$ 860.00