Nafamostat mesylate

SKU: orb1305551

Description

Nafamostat mesylate

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	82956-11-4
MW	539.58
Purity	99.70%
Formula	C₁₉H₁₇N₅O₂·2CH₄O₃S
SMILES	CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
Target	Apoptosis,SARS-CoV,Serine Protease,TNF,Anti-infection,NF-κB
Solubility	DMSO:121 mg/mL (224.25 mM);H2O:54 mg/mL (100.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.41 mM)

Bioactivity

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In Vivo

Nafamostat mesilate significantly inhibits the release of platelet β-thromboglobulin (βTG) and the release of elastase from neutrophils. It also prevents the formation of complexes between the C1 inhibitor and both prekallikrein and FXIIa. Furthermore, Nafamostat mesilate inhibits the extrinsic pathway activity mediated by the TF-F.VIIa complex, leading to the production of F.Xa, with an IC50 value of 0.1 μM.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Serine Protease, Ser/Thr Protease, Serine endopeptidases, Serine kinase, threoninkinase, Threonine proteases, threonin kinase, SerineProtease, Serinekinase, Serine proteases, SARS-CoV, SARSCoV, SARS coronavirus, FUT175, FUT-175, FUT 175, Inhibitor, Nafamostat, Nafamostat mesylate, Nafamostat Mesylate, inhibit, Apoptosis

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Compound Identifiers

PubChem CID

5311180 ↗

Key Properties

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No computed properties available.

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