NDMC101

SKU: orb1298841

Description

NDMC101 is a small molecule research compound that functions as a dual inhibitor of dipeptidyl peptidase-IV (DPP-IV) in T cells and the transcription factors NFATc1 and NF-κB, thereby demonstrating immunomodulatory properties. Its applications include in vitro studies of T-cell activation and inflammation, as well as in vivo research on autoimmune and inflammatory disease models.

Research Area

Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1308631-40-4
MW	265.67
Purity	99.59%
Formula	C₁₃H₉ClFNO₂
SMILES	Oc1ccccc1C(=O)Nc1ccc(Cl)cc1F
Target	Proteasome,NF-κB
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.53 mM);DMSO:11 mg/mL (41.4 mM)

Bioactivity

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In Vivo	In CIA mice, oral administration of NDMC101 reduced arthritic index and mitigated bone erosion. Serum TNF-α and IL-1β concentrations in these mice were decreased significantly at the higher dose of 62.5 mg/kg. Read more...
In Vitro	NDMC101 markedly inhibited RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs). Moreover, pit formation assay showed that NDMC101 significantly reduced the bone-resorbing activity of mature osteoclasts. Read more...
Cell Research	Differentiation into osteoclast-like cells was examined by tartrate-resistant acid phosphatase (TRAP) staining and expression of osteoclast differentiation markers. Read more...
Animal Research	Collagen-induced arthritis (CIA) mice were administered test articles by gavages to assess its efficacy. Then clinical, histological, and biochemical parameters were assessed to determine the effects of N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide (NDMC101) on synovial inflammation and bone erosion by hematoxlin and eosin staining and Enzyme-linked immunosorbent assay (ELISA). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dipeptidyl Peptidase, DPP, Bone, bone destruction, marrow-derived macrophages, Inhibitor, inhibit, NSAID, Nuclear factor-kappaB, Nuclear factor-κB, osteoblast, osteoclastogenesis, NF-κB, NFκB, NFkB, NF-kB, NDMC 101, NDMC101, NDMC-101, synovial inflammation, rheumatoid arthritis, RAW 264.7

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Compound Identifiers

PubChem CID

60202556 ↗

Key Properties

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No computed properties available.

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NDMC101 (orb1298841)

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Purity:	>98% (HPLC)
CAS Number:	1308631-40-4
MW:	265.66
Formula:	C₁₃H₉ClFNO₂

NDMC101

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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