Nicotredole

SKU: orb1303266

Description

Nicotredole (Tryptamide) is an orally bioavailable small molecule with analgesic and anti-inflammatory properties. Its anti-inflammatory potency is comparable to phenylbutazone, but it demonstrates significantly lower ulcerogenic activity, making it a useful research tool for in vivo pain and inflammation models.

Images & Validation

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Key Properties

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CAS Number	29876-14-0
MW	265.31
Purity	99.67%
Formula	C₁₆H₁₅N₃O
SMILES	O=C(NCCc1c[nH]c2ccccc12)c1cccnc1
Target	Others
Solubility	DMSO:25 mg/mL (94.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

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In Vivo

Nicotredole exhibits anti-inflammatory properties as evidenced by its effectiveness in reducing carrageenin-induced paw edema in rats. Additionally, it has been shown to counteract pyrogen-induced hyperthermia, offer analgesic benefits, extend hexobarbital-induced sleep duration, and suppress locomotor activities in both rats and mice. Intraperitoneally (i.p.), Nicotredole holds lethal doses (LD50) of 1260 mg/kg for male rats and 1980 mg/kg for male mice, whereas orally (p.o.), its LD50 values are 8.5 g/kg for male rats and 9.3 g/kg for male mice. Administered either orally or intraperitoneally at a dose of 25 mg/kg, Nicotredole is rapidly absorbed and eliminated, with half-lives ranging from 4.92 to 17.5 minutes for absorption and 55.72 to 74.52 minutes for elimination. It achieves maximum concentration (C max) levels of 11-13 μg/cm^3 within 30 minutes, resulting in area under the curve (AUC) values between 21.40 and 27.30 μg•h/cm^3.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, Nicotredole, anti-inflammatory, analgesic, ulcerogenic, Tryptamide

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Compound Identifiers

PubChem CID

65768 ↗

Key Properties

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No computed properties available.

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Nicotredole (orb1303266)

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Nicotredole

Description

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Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Compound Identifiers

Key Properties

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Nicotredole (orb1303266)

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