Nisin Z

SKU: orb1981185

Description

Nisin Z is a research compound that attenuates inflammation by suppressing the ERK1/2 and p38 MAPK pathways. It has demonstrated efficacy in reducing pro-inflammatory cytokine release in models such as LPS-induced mastitis, making it relevant for studying inflammatory diseases in both cellular and animal systems.

Research Area

Infectious Disease & Virology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	137061-46-2
MW	3331.03
Formula	C₁₄₁H₂₂₉N₄₁O₃₈S₇
SMILES	O=C(NC(C(=O)O)CCCCN)C(=C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1NC(=O)C(NC(=O)C2NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C3NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C4NC(=O)CNC(=O)C5N(C(=O)C(NC(=O)C6NC(=O)C(NC(=O)C(=C)NC(=O)C(NC(=O)C(NC(=O)C(=CC)NC(=O)C(N)C(C)CC)CSC6)C(C)CC)CC(C)C)C(SC4)C)CCC5)CCCCN)C(SC3)C)C)CC(C)C)CCSC)CC(=O)N)CCSC)CCCCN)C(SC2)C)C)C(SC1)C)CC(=O)N)CO)C(C)CC)CC7=CN=CN7)C(C)C
Target	p38 MAPK,ERK,Antibacterial,Antifungal
Solubility	H2O:8 mg/mL (2.4 mM);DMSO:1 mg/mL (0.3 mM)

Bioactivity

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In Vivo

Nisin Z (1, 5 and 10 mg/kg, intraperitoneal injection) helps to prevent pathological damage in LPS-induced mouse mastitis model.

In Vitro

Nisin Z (10 μg/mL, 24 h) promoted the detachment and differentiation of gingival fibroblasts.Nisin Z (25-75 μg/mL, 24 h) inhibited the adhesion of C. albicans to gingival cells. Nisin Z (500 and 1000 μg/mL, 24 hours) inhibited the formation of germ tubes in C. albicans. Nisin Z (100 μg/mL, 12 h) decreased LPS-induced secretion of pro-inflammatory cytokines (e.g., IL-6, TNF-α, IL-1β) in MCF10A cells Nisin Z (10-100 μg/mL, 12 h) inhibited LPS-induced activation of the ERK1/2 and p38 MAPK signaling pathways in MCF10A cells.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

169491536 ↗

Key Properties

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No computed properties available.

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Nisin Z (orb1981185)

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Nisin Z

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

Nisin Z (orb1981185)

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