NOD1/2 antagonist-1

SKU: orb1744880

Description

This dual NOD1/NOD2 antagonist exhibits IC50 values of 1.13 µM and 0.77 µM, respectively, with a half-life of 67.6 minutes. It is a valuable research tool for studying innate immune signaling and has been shown in research to enhance the antitumor effects of chemotherapeutics like paclitaxel in experimental models.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2704623-69-6
MW	663.03
Purity	99.69%
Formula	C₃₂H₂₈ClF₅N₄O₄
SMILES	O=C(NCCCOC1=CC=C(C=C1)C(F)(F)F)C2=CC=3N=CN(C(=O)C3C=C2C=4C=CC=C(Cl)C4)CC(=O)N5CCCC(F)(F)C5
Target	NOD,NOD-like Receptor (NLR)
Solubility	DMSO:25 mg/mL (37.71 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

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Target IC50	NOD2:0.77 μM\|NOD1:1.13 μM
In Vivo	In the B16 tumor-bearing model, NOD1/2 antagonist-1 (50 mg/kg, intravenous injection, once every other day for 16 days) significantly enhanced the anti-tumor effect of paclitaxel (PTX) . Read more...
In Vitro	NOD1/2 antagonist-1 (0-10 μM, 3 hours) can inhibit C12-iE-DAP-induced or MDP-induced NF-κB activation . NOD1/2 antagonist-1 (0-10 μM, 1 hour) suppresses inflammatory responses by activating NOD1 and NOD2 . NOD1/2 antagonist-1 (0-10 μM, 1 hour) sustainably and dose-dependently reduces the transcriptional levels of IL-6, TNF-α, and IL-8 . Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

156788057 ↗

Key Properties

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No computed properties available.

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