Nodinitib-1

SKU: orb1300633

Description

Nodinitib-1 (CID-1088438) is a selective small molecule inhibitor of NOD1, demonstrating potent activity with an IC50 of 0.56 µM. This compound is a valuable research tool for investigating the role of NOD1 in inflammatory and immune pathways in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	799264-47-4
MW	287.34
Purity	>99.99% (May vary between batches)
Formula	C₁₄H₁₃N₃O₂S
SMILES	Cc1ccc(cc1)S(=O)(=O)n1c(N)nc2ccccc12
Target	NOD-like Receptor (NLR),TNF,NOD
Solubility	DMSO:28.7 mg/mL (99.88 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.96 mM);Ethanol:2.9 mg/mL (10.09 mM)

Bioactivity

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Target IC50	NOD1:0.56 μM
In Vitro	Nodinitib-1 has shown selective inhibition of NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity and is selected as a probe candidate molecule. Nodinitib-1 is also confirmed in secondary assays by selectively inhibiting NOD1-dependent IL-8 secretion and also selectively inhibiting the NOD1-dependent pathway to NF-κB activation. In another research, Nodinitib-1 is proved to cause conformational changes of NOD1 in vitro and alter NOD1 subcellular targeting in cells, providing chemical probes for interrogating mechanisms regulating NOD1 activity and tools for exploring the roles of NOD1 in various infectious and inflammatory diseases. Read more...
Cell Research	Hepatic toxicity of compounds is determined with Fa2N-4 immortalized human hepatocytes using the ATP-lite 1-step assay. Fa2N-4 cells are seeded at 50,000 cells/well, and incubated with a range of concentrations of the test compound (0.01 μM-50 μM) in MFE support medium for 24 h at 37 ℃, 5% CO2. At the end of the experiment D-luciferin and luciferase are added. The emitted luminescent signal produced as a result of the reaction with cellular ATP is captured on the Infinite M200 plate reader. The concentration of each compound that killed 50% of the cells (LC50) is calculated by non-linear regression analysis using a log (inhibitior) vs response equation with a variable slope, using the statistic software package Prism4.(Only for Reference) Read more...

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CID 1088438, CID1088438, CID-1088438, NLR, NOD1, NOD2, NOD-like Receptor, Nodinitib 1, Nodinitib1, Nodinitib-1, NODlike Receptor (NLR), NOD-like Receptor (NLR), NODlikeReceptor, NODlikeReceptor(NLR), ML 130, ML130, ML-130, inhibit, Inhibitor, TNF-α

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Compound Identifiers

PubChem CID

1088438 ↗

Key Properties

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No computed properties available.

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Nodinitib-1 (orb1300633)

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Purity:	>98% (HPLC)
CAS Number:	799264-47-4
MW:	287.3369
Formula:	C₁₄H₁₃N₃O₂S

Nodinitib-1

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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