Nortrachelogenin

SKU: orb1682000

Description

Nortrachelogenin ((-)-Wikstromol) is a bioactive lignan isolated from Patrinia scabiosaefolia. It exhibits antifungal properties through membrane disruption and induces apoptosis via a cysteinyl aspartate-specific protease-dependent pathway, making it a compound of interest for microbiological and cancer research.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	34444-37-6
MW	374.38
Purity	99.86% (May vary between batches)
Formula	C₂₀H₂₂O₇
SMILES	COc1cc(C[C@H]2COC(=O)[C@]2(O)Cc2ccc(O)c(OC)c2)ccc1O
Target	Antifungal,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.67 mM);DMSO:55 mg/mL (146.91 mM)

Bioactivity

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In Vitro	Methanolic extract of the root bark of carissa edulis showed anti-plasmodial activity against the chloroquin-senitive (D6) strains of plasmodium falciparum parasite with an IC50 value of 1.95 Dg/ml. From this extract, a lignan compound Nortrachelogenin was isolated and showed anti-plasmodium activity of 14.50 Dg/ml. The structure was determined on the basis of spectroscopic evidence. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ROS, TNF-α, Wikstromol, PGE, HIV, IGF-1R, Fungal, NO, NF-κB, NOS, Nortrachelogenin, IL Receptor, COX, (-)-Nortrachelogenin, (-)-Wikstromol, Akt, Caspase, Apoptosis, Antifection

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Compound Identifiers

PubChem CID

394846 ↗

Key Properties

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No computed properties available.

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