NOTCH4 (C) Antibody, Rabbit Polyclonal

SKU: orb67113

Description

Rabbit polyclonal to NOTCH4.Neurogenic locus notch homolog protein 4 (NOTCH4) is a single pass membrane protein that belongsto the NOTCH family. NOTCH4 functions as a receptor for membrane-bound ligands Jagged1,Jagged2 and Delta1 to regulate cell-fate determination. NOTCH4 is cleaved upon ligand activationand the notch intracellular domain (NICD) is released, which forms a transcriptional activator complexwith RBPJ/RBPSUH to activate genes of the enhancer of split locus. It affects the implementation ofdifferentiation, proliferation and apoptotic programs.

Research Area

Cardiovascular Disease, Developmental Biology, Epigenetics, Stem Cells

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:500-1:2000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human NOTCH4
Molecular Weight	210
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-NOTCH4 antibody,anti-Neurogenic locus notch homolog protein 4 antibody,anti-Notch 4 antibody,anti-hNotch4 antibody,anti-INT3 antibody

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Western blot analysis of total cell extracts from human Jurkat using NOTCH4 antibody

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UniProt

Q99466

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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