OPTN (N) Antibody, Rabbit Polyclonal

SKU: orb107111

Description

Rabbit polyclonal to OPTN. Optineurin (OPTN) plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. OPTN links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. OPTN negatively regulates the induction of IFNB in response to RNA virus infection. Additionally, OPTN plays a neuroprotective role in the eye and optic nerve. OPTN is also probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), and it also may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Research Area

Autophagic, Cancer, Epigenetics, Immunology, Infectious Diseases, Neuroscience, Signaling Pathways

Images & Validation

−

Item 1 of 1

Tested Applications	WB
Reactivity	Human, Mouse

Key Properties

−

Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human OPTN
Molecular Weight	66
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

−

Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Western blot of total cell extracts from (A) mouse brain, (B) mouse thymus, (C) human HeLa, (D) human Jurkat; using anti-OPTN (N) (orb107111) at RT for 2 h.

Quick Database Links

UniProt

Q96CV9

UniProt Details

−

No UniProt data available

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Western Blot (IB, immunoblot)

View Protocol

Find More Protocols