Osimertinib-13C,d3

SKU: orb3138285

Description

Osimertinib-13C,d3 is a deuterated form of Osimertinib labeled with 13C. Osimertinib (AZD9291) is an orally active, covalent, irreversible EGFR inhibitor with mutation selectivity, effectively inhibiting L858R (IC50=12 nM) and L858R/T790M (IC50=1 nM) EGFR mutations. It addresses resistance to EGFR inhibitors caused by the T790M mutation in lung cancer.

Images & Validation

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Key Properties

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CAS Number	2254100-49-5
MW	503.62
Formula	C₂₈H₃₃N₇O₂
SMILES	CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCN(C)C)[13C]([2H])([2H])[2H])C(NC(C=C)=O)=C4)=NC=C3
Target	EGFR

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

EGFR

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