Oxysanguinarine

SKU: orb1297254

Description

Oxysanguinarine is a bioactive alkaloid with demonstrated antiplatelet aggregation effects and potential antiviral activity against dengue virus. It is a valuable research tool for studying cardiovascular biology and virology in in vitro experimental models.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	548-30-1
MW	347.32
Purity	99.57% (May vary between batches)
Formula	C₂₀H₁₃NO₅
SMILES	CN1C=2C(C=3C(C1=O)=C4C(=CC3)OCO4)=CC=C5C2C=C6C(=C5)OCO6
Target	Parasite
Solubility	Methanol:Insoluble;DMF:< 1 mg/mL (insoluble or slightly soluble);DMSO:Insoluble;Ethanol:Insoluble

Bioactivity

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In Vitro

A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in humans for a long-time. The ADMET studies, molecular docking and density functional theory (DFT) based analysis was carried out to determine the potential inhibitory properties of these phytochemicals. The ADMET analysis and docking results revealed nine phytochemicals, i.e. Silymarin, Flavobion, Derrisin, Isosilybin, Mundulinol, Silydianin, Isopomiferin, Narlumicine and Oxysanguinarine to have potential inhibitory properties against DENV and can be considered for additional in vitro and in vivo studies to assess their inhibitory effects against DENV replication. They exhibited binding affinity ≥ -8 kcal/mol against DENV4-NS4B. Furthermore, DFT-based analysis revealed high reactivity for these nine phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap. INTERPRETATION &

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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8-Oxosanguinarine, antimalarial, Antifection, falciparum strain, Hydroxysanguinarine, Parasite, Plasmodium, Oxysanguinarine

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Compound Identifiers

PubChem CID

443716 ↗

Key Properties

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No computed properties available.

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