Ozagrel hydrochloride

SKU: orb1300606

Description

Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A2 synthase inhibitor. It is applied in research to study cerebral vasospasm and ischemia, with both in vitro enzymatic assays and in vivo models of post-operative stroke and related ischemic conditions.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	78712-43-3
MW	264.71
Purity	99.80% (May vary between batches)
Formula	C₁₃H₁₂N₂O₂·HCl
SMILES	Cl.OC(=O)\C=C\c1ccc(Cn2ccnc2)cc1
Target	Prostaglandin Receptor,Thrombin
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.56 mM);DMSO:65 mg/mL (245.55 mM);H2O:48 mg/mL (181.33 mM);Ethanol:6 mg/mL (22.67 mM)

Bioactivity

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Target IC50

TXA2 synthase:11 nM

In Vitro

Administration of 3 mg/kg Ozagrel significantly reduces the area and volume of cortical infarcts in rats following cerebral middle artery occlusion and reperfusion. Ozagrel also inhibits neural deficits in a rat model of microthrombosis and enhances deteriorated spontaneous motor activity and motor coordination in a conscious mouse model of cerebral ischemia-reperfusion. Furthermore, Ozagrel prevents the increase in lactate dehydrogenase activity in guinea pig pulmonary lavage fluid and blocks the production of thromboxane A(2) induced by oleic acid in guinea pigs, subsequently reducing the total protein concentration and the numbers of macrophages and neutrophils, as well as the expression of monocyte chemoattractant protein-1 and interleukin-8 mRNA in the entire lung. In cats, Ozagrel inhibits the reduction of brain tissue-specific gravity induced by reperfusion in the SHR model of cerebral ischemia-reperfusion and restores the decreased cortical PO(2) post-ischemia upon reperfusion. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostacyclin I(2) (PGI(2)), in the brain tissue following ischemia-reperfusion.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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TXA2, ProstaglandinReceptor, Prostaglandin Receptor, platelet, Ozagrel, Ozagrel HCl, Ozagrel Hydrochloride, Ozagrel hydrochloride, thromboxane A2, Thromboxane A2 synthetase, antiplatelet, aggregation, inhibit, Inhibitor, OKY 046, OKY046, OKY-046, OKY-046 HCl

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Compound Identifiers

PubChem CID

6438130 ↗

Key Properties

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No computed properties available.

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