Ozanimod

SKU: orb1300342

Description

Ozanimod

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1306760-87-1
MW	404.46
Purity	99.37%
Formula	C₂₃H₂₄N₄O₃
SMILES	CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1cccc2[C@H](CCc12)NCCO
Target	LPL Receptor,S1P Receptor
Solubility	Ethanol:10 mg/mL (24.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.94 mM);DMSO:41.67 mg/mL (103.03 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50	S1P5 receptor:11 nM(EC50)\|S1P1 receptor:0.41 nM(EC50)
In Vivo	in vivo Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses Clinicalal symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits Clinicalal and histological disease scores. In a naive CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measurin the degree of inflammation, g and loss, hyperplasia, neutrophil infiltrate and mucosal thickness. Read more...
In Vitro	In S1P1R HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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neurosurgery, Ozanimod, Lysophospholipid Receptor, LPL Receptor, LPLReceptor, LPL, inhibit, multiple sclerosis (MS), Inhibitor, RPC1063, RPC-1063, RPC 1063, S1P1, S1PReceptor, S1P5, S1P receptor subtypes 1 (S1P1), S1P receptor subtypes 5 (S1P5), S1P Receptor, sphingosine 1-phosphate (S1P)

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Compound Identifiers

PubChem CID

52938427 ↗

Key Properties

−

No computed properties available.

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Ozanimod (orb1300342)

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MW:	418.45
Formula:	C₂₃H₂₂N₄O₄

CAS Number:	1306760-73-5
MW:	360.41
Formula:	C₂₁H₂₀N₄O₂

CAS Number:	1306761-08-9
MW:	402.45
Formula:	C₂₃H₂₂N₄O₃

Purity:	0.98
MW:	418.45
Formula:	C₂₃H₂₂N₄O₄

Purity:	99.81%
CAS Number:	1618636-37-5
MW:	440.92
Formula:	C₂₃H₂₅ClN₄O₃

Ozanimod

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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