Ozanimod hydrochloride

SKU: orb1687492

Description

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1618636-37-5
MW	440.92
Purity	99.81%
Formula	C₂₃H₂₅ClN₄O₃
SMILES	N(CCO)[C@@H]1C=2C(=C(C=CC2)C=3N=C(ON3)C4=CC(C#N)=C(OC(C)C)C=C4)CC1.Cl
Target	S1P Receptor,LPL Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.34 mM);DMSO:150 mg/mL (340.2 mM)

Bioactivity

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Target IC50	S1P5 receptor:8.6 nM (EC50)\|S1P1 receptor:1.03 nM (EC50)
In Vivo	I the Experimental autoimmune encephalomyelitis (EAE) model, Ozanimod hydrochloride (0.05, 0.2, or 1 mg/kg; oral gavage; once daily; for 14 consecutive days) alleviated weight loss, with significantly reduced terminal disease scores observed in the 0.2 and 1 mg/kg dose groups. Moreover, cell counts were significantly reduced in All dose group. Read more...
In Vitro	Ozanimod hydrochloride, as a sphingosine-1-phosphate (S1P) receptor modulator, selectively binds with high affinity to S1P receptor subtypes 1 (S1P1) and S1P. Read more...

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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BMS-986374 hydrochloride, RPC-1063 hydrochloride, S1P, S1P Receptor, S1PReceptor

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Compound Identifiers

PubChem CID

91618104 ↗

Key Properties

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No computed properties available.

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