PAK2 (N2) Antibody, Rabbit Polyclonal

SKU: orb67263

Description

Rabbit polyclonal to PAK2.p21-activated kinase 2 (PAK2) belongs to the protein kinase superfamily, STE Ser/Thr protein kinasefamily and STE20 subfamily. PAK2 plays a role in a variety of different signaling pathways includingcytoskeleton regulation, cell motility, cell cycle progression, apoptosis and proliferation. PAK2 acts asdownstream effector of the small GTPases CDC42 and RAC1. Activation of PAK2 by the binding ofactive CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylationof PAK2. Activated PAK2 can phosphorylate many substrates including histone H4, BAD, ribosomalprotein S6 and MBP. Additionally, PAK2 associates with ARHGEF7 to perform kinaseindependentfunctions such as spindle orientation control during mitosis. On the other hand, apoptoticstimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34 thattranslocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway.

Research Area

Apoptotic, Cancer, Epigenetics, Infectious Diseases, Neuroscience, Signaling Pathways

Images & Validation

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Item 1 of 1

Tested Applications	WB
Dilution Range	WB:1:500-1:2000
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human PAK2
Molecular Weight	58
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti-PAK2 antibody,anti-Serine antibody,anti-threonineprotein kinase PAK 2 antibody,anti-GammaPAK antibody,anti-PAK65 antibody,anti-S6 antibody,anti-H4 kinase antibody,anti-p21activated kinase 2 antibody,anti- PAK2 antibody,anti-p58 antibody

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Western blot analysis of total cell extracts from human Hela(Lane1),human Jurkat(Lane2), mouse thymus(Lane3) and mouse brain(Lane4) using PAK2 antibody

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UniProt

Q13177

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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