Palbociclib hydrochloride

SKU: orb1686464

Description

Palbociclib hydrochloride is the salt form of a selective, orally bioavailable CDK4/6 inhibitor. It is widely used in breast cancer research and has demonstrated anti-proliferative activity in both in vitro assays and in vivo models, including studies for hepatocellular carcinoma.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	571189-11-2
MW	520.46
Purity	99.89% (May vary between batches)
Formula	C₂₄H₃₁Cl₂N₇O₂
SMILES	Cl.Cl.CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O
Target	CDK
Solubility	H2O:1 mg/mL (1.92 mM)

Bioactivity

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Target IC50	CDK6-CyclinD2:16 nM\|CDK4-CyclinD1:11 nM\|CDK4-CyclinD3:9 nM\|Dyrk1A:2000 nM\|MAPK:8000 nM
In Vivo	Methods: Palbociclib hydrochloride (40 mg/kg, oral, 17 days) was used to treat NSG mice bearing IMR32 neuroblastoma cells to study its effect on tumor growth in mice. Results: Palbociclib hydrochloride effectively inhibited tumor growth in NSG mice and had no obvious toxicity to mice. Read more...
In Vitro	Methods: Huh7 and skHep1 cells were treated with Palbociclib hydrochloride (0.1, 0.5 μM, 10 days) to test the reversibility of cell cycle arrest. Results: Palbociclib hydrochloride may induce irreversible cell cycle arrest in both cell lines, which may be dose-dependent. Read more...

Storage & Handling

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Storage	keep away from moisture \| store at 4°C \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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PD0332991 hydrochloride, PD-0332991 hydrochloride, TQB3616 hydrochloride, TQB-3616 hydrochloride

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Compound Identifiers

PubChem CID

60167560 ↗

Key Properties

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No computed properties available.

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