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Parecoxib

SKU: orb1307460

Description

Parecoxib (SC 69124) is a potent and selective cyclooxygenase-2 (COX-2) inhibitor. It is widely used in research for investigating pain, inflammation, and fever mechanisms, serving as a valuable tool in both in vitro enzymatic assays and in vivo animal models of inflammation.

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

Key Properties

CAS Number198470-84-7
MW370.42
Purity99.90%
FormulaC19H18N2O4S
SMILESCC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3
TargetCOX
SolubilityDMSO:50 mg/mL (134.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.4 mM);Ethanol:2 mg/mL (5.4 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

In Vivo
Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

coxibs, COX-2, Cyclooxygenase, COX, chronic inflammatory condition, cognitive dysfunction, analgesia, pain, Parecoxib, inhibit, Inhibitor, SC 69124, SC69124, SC-69124, rheumatoid arthritis, postoperative, osteoarthritis, POCD, Valus-P, Vorth-P

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Key Properties

No computed properties available.

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Parecoxib (orb1307460)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

10 mg
$ 70.00
25 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
50 mg
$ 120.00
100 mg
$ 170.00
200 mg
$ 220.00
500 mg
$ 340.00
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