Paromomycin Sulfate

SKU: orb1309761

Description

Paromomycin Sulfate

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	1263-89-4
MW	713.71
Purity	99.86%
Formula	C₂₃H₄₇N₅O₁₈S
SMILES	OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
Target	Parasite,Antibiotic,Antibacterial
Solubility	H2O:255 mg/mL (357.29 mM);DMSO:Insoluble

Bioactivity

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In Vivo

Paromomycin, an aminoglycoside antibiotic, exhibits robust antimicrobial activity against a broad spectrum of Gram-positive bacteria, Gram-negative bacteria, some protozoa, and tapeworms. In vitro analysis of amastigote sensitivity within a mouse macrophage model indicated that L. tropica an the L. major strains (ED50s: 1~5 μM) are more sensitive to Paromomycin than L. mexicana (ED50: 39 μM) and L. braziliensis (ED50: < 2 μM) the L. donovani strain demonstrates moderate sensitivity (ED50: 6~18 μM), wit the exception o the Indian strain, DD8, exhibiting significantly reduced susceptibility (ED50 > 50 μM).

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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tapeworm infection, Parasite, parasitic, Paromomycin, Paromomycin Sulfate, Paromomycin sulfate salt, leishmaniasis, giardiasis, Aminosidine, Aminosidine sulfate, amebiasis, Antibiotic, Bacterial, 16S rRNA

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Compound Identifiers

PubChem CID

441375 ↗

Key Properties

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No computed properties available.

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