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PDE4-IN-29

SKU: orb3135547

Description

PDE4-IN-29 (Compound 55) is an orally active and selective inhibitor of PDE4, targeting subtypes such as PDE4A1, PDE4B2, and PDE4D3, with an IC50 value for PDE4D3 of less than 5 nM. It inhibits the degradation of cyclic adenosine monophosphate (cAMP), elevating intracellular cAMP levels and suppressing the release of inflammatory mediators like TNF-α. PDE4-IN-29 holds potential for research in inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.

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Key Properties

CAS Number2815361-45-4
MW546.63
FormulaC27H34N2O8S
SMILESO=C1C=2C(C(=O)N1[C@H](CS(C)(=O)=O)C3=CC(OCC)=C(OC)C=C3)=C(NC(C)=O)C=CC2C(CCCC)O
TargetPDE

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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PDE4-IN-29 (orb3135547)

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