Pevonedistat hydrochloride

SKU: orb1706960

Description

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1160295-21-5
MW	479.98
Purity	99.19%
Formula	C₂₁H₂₆ClN₅O₄S
SMILES	N(C1=C2C(N(C=C2)[C@@H]3C[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=N1)[C@@H]4C=5C(CC4)=CC=CC5.Cl
Target	NEDD8,Apoptosis
Solubility	H2O:8 mg/mL (16.67 mM);DMSO:80 mg/mL (166.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.88 mM)

Bioactivity

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Target IC50	NAE:4.7 nM
In Vivo	METHODS: To investigate the mechanism and therapeutic effects ofPevonedistat hydrochloride as an effective and selective NAE inhibitor. RESULTS: Pevonedistat hydrochloride disrupted cullin-RING ligase-mediated protein turnover, leading to apoptosis in human tumor cells and inhibition of human tumor xenograft growth in mice. Read more...
In Vitro	METHODS: To determine the effects of Pevonedistat hydrochloride on cell viability and clonogenic survival in four gastric cancer cell lines, cells were treated with different concentrations of Pevonedistat hydrochloride (0.01-4 μM) for 72 hours, followed by viability assays based on the ATP-lite assay. RESULTS: Three of the gastric cancer cell lines were more sensitive to the growth inhibitory effects of Pevonedistat hydrochloride than GES-1 cells . Read more...

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, NEDD8, NAE, MLN 4924 hydrochloride, MLN4924 hydrochloride, MLN-4924 hydrochloride

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Compound Identifiers

PubChem CID

66576990 ↗

Key Properties

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No computed properties available.

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