Phospho-NDRG1 (Thr346) (F5) rabbit mAb PE conjugate Antibody

SKU: orb1946263

Description

N-Myc down-regulated gene 1 (NDRG1) has been reported to be a direct transcriptional target of p53. NDRG1 appears to play a necessary, but not sufficient, role in apoptosis, though its exact mechanism of action remains unknown. NDRG1 expression is elevated in non-small cell lung cancer cells, promoting cancer growth and reducing cytotoxicity to certain anti-cancer drugs. NDRG1 is also elevated in solid tumors and is recognized as a negative prognostic indicator in breast cancer. Elevated NDRG1 expression is correlated with disease recurrence and metastasis in breast cancer. NDRG1 is phosphorylated by Sgk1, which itself is activated by mTORC2. Phosphorylation of NDRG1 at Thr346 promotes cellular differentiation in adipocytes.

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Tested Applications	FC
Dilution Range	For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Monoclonal
Isotype	Rabbit IgG1k
Clone No.	NDRG1T346-F5
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Thr346 of human phospho NDRG1
Purification	Protein A+G
Conjugation	PE

Storage & Handling

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Storage	2-8°C
Form/Appearance	Liquid
Buffer/Preservatives	1X PBS, 0.09% NaN3, 0.2% rAlbumin
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Differentiation-related gene 1 protein, N-myc downstream-regulated gene 1 protein, Nickel-specific induction protein Cap43, Reducing agents and tunicamycin-responsive protein, RTP, Rit42

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Phospho-NDRG1 (Thr346) (F5) rabbit mAb PE conjugate Antibody

Flow cytometry of THP1 cells unstained and untreated as negative control (blue) or stained and untreated (red) or stained and treated with IFNa plus IL-4 and pervanadate (green) using phospho-NDRG1 (Thr346) (F5) rabbit mAb, NDRG1T346-F5 PE conjugate, Cat# orb1946263.

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UniProt

Q92597

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No UniProt data available

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Protocol Information

Flow Cytometry

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