Phospho-PLCg1 (Tyr783) (C4) rabbit mAb PE conjugate Antibody

SKU: orb1946202

Description

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositolphosphate to inositol triphosphate and diacylglycerol. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate diacylglycerols (DAGs) and water-soluble phosphorylated derivatives, such as inositol 1,4,5-triphosphate (IP3).„ÄÄWithin the PLC family, PLCg is the only member that contains SH2 and SH3 domains, necessary for phospho PLCg activation. Phospho PLCg, upon activation, can interact with receptor tyrosine kinases.

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Tested Applications	FC
Dilution Range	For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Monoclonal
Isotype	Rabbit IgG1k
Clone No.	PLCG1Y783-C4
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Tyr783 of human phospho PLCg1.
Purification	Protein A+G
Conjugation	PE

Storage & Handling

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Storage	2-8°C
Form/Appearance	Liquid
Buffer/Preservatives	1X PBS, 0.09% NaN3, 0.2% rAlbumin
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, Phospholipase C-gamma-1, PLC-gamma-1, PLC1

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Phospho-PLCg1 (Tyr783) (C4) rabbit mAb PE conjugate Antibody

Flow cytometric analysis of Hela cells unstained imatinib treated (blue) or stained treated with imatinib (red) or with pervanadate (green) using phospho-PLCγ1 (Tyr783) antibody PLCg1Y783-C4 PE conjugate. Cat. #orb1946202.

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UniProt

P19174

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No UniProt data available

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Protocol Information

Flow Cytometry

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