Phospho-Stat6 (Tyr641) (G12) rabbit mAb FITC conjugate Antibody

SKU: orb1946354

Description

The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.

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Tested Applications	FC
Dilution Range	For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Monoclonal
Isotype	Rabbit IgG1k
Clone No.	Stat6Y641-G12
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Purification	Protein A+G
Conjugation	FITC

Storage & Handling

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Storage	2-8°C
Form/Appearance	Liquid
Buffer/Preservatives	1X PBS, 0.09% NaN3, 0.2% rAlbumin
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Signal transducer and activator of transcription 6, IL-4 Stat

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Phospho-Stat6 (Tyr641) (G12) rabbit mAb FITC conjugate Antibody

Flow cytometric analysis of U937 cells unstained cells negative control (blue) or stained and untreated (red) or treated with IFNa and IL-4 (green) using Phospho-Stat6 (Tyr641) -FITC antibody Stat6Y641-G12-FITC. Cat. #orb1946354.

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UniProt

P42226

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No UniProt data available

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Protocol Information

Flow Cytometry

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