Phospho-Stat6 (Tyr641) (G12) rabbit mAb PE conjugate Antibody

SKU: orb1946355

Description

The transcription factor Stat6 is a member of the signal transducers and activators of transcription (STAT) family of proteins. Stat6 is the only member of this family that is activated by interleukin-4 (IL-4), after which Stat6 is both tyrosine- and serine-phosphorylated by Jak kinases. The consensus Stat6 binding site TTCN4GAA is found in the promoters of many genes regulated by IL-4. In T lymphocytes, Stat6 is required for differentiation into Th2 cells in response to IL-4. Stat6 may play a role in solid tumorigenesis; a large immunohistochemistry study of Stat6 expression in over 2,000 tumor samples confirmed strong nuclear staining.

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Tested Applications	FC
Dilution Range	For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Monoclonal
Isotype	Rabbit IgG1k
Clone No.	Stat6Y641-G12
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Purification	Protein A+G
Conjugation	FITC

Storage & Handling

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Storage	2-8°C
Form/Appearance	Liquid
Buffer/Preservatives	1X PBS, 0.09% NaN3, 0.2% rAlbumin
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Signal transducer and activator of transcription 6, IL-4 Stat

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Phospho-Stat6 (Tyr641) (G12) rabbit mAb PE conjugate Antibody

Flow cytometric analysis of U937 cells unstained and untreated cells as negative control (blue) or stained and untreated (red) or treated with IFNa and IL-4 (green) using Phospho-Stat6 (Tyr641) -G12 antibody Stat6Y641-G12 PE conjugate. Cat. #orb1946355.

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UniProt

P42226

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No UniProt data available

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Protocol Information

Flow Cytometry

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