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PIK-75

SKU: orb1305193

Description

PIK-75 is a potent dual inhibitor of DNA-PK and PI3K, exhibiting low nanomolar IC50 values against DNA-PK (2 nM) and p110α (5.8 nM), with additional activity against p110γ (76 nM). This small molecule is a valuable research tool for investigating DNA damage response and PI3K signaling pathways in both cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number372196-67-3
MW452.28
Purity>99.99% (May vary between batches)
FormulaC16H14BrN5O4S
SMILESCN(\N=C\c1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
TargetApoptosis,DNA-PK,PI3K
SolubilityDMSO:4.53 mg/mL (10.02 mM)

Bioactivity

Target IC50
DNA-PK:2 nM|p110δ:510 nM|ATR:21 μM|p110γ:76 nM|p110α:5.8 nM|PI4KIIIβ:50 μM|ATM:2.3 μM|hsVPS34:2.6 μM|PI3KC2β:1 μM|p110β:1.3 μM|mTORC1:1 μM|mTORC2:10 μM|PI3KC2α:10 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DNA-dependent protein kinase, DNAPK, DNA-PK, cells, CHO-IR, apoptotic, Apoptosis, cancer, pancreatic, inhibit, Inhibitor, PKB, PI3K, Phosphoinositide 3-kinase, PIK 75, PIK75, PIK-75, p110α, p110β, p110γ, p110δ

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Key Properties

No computed properties available.

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Protocol Information

PIK-75 (orb1305193)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 240.00
100 mg
$ 340.00
DispatchUsually dispatched within 3-5 working days
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