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Pinostrobin

SKU: orb1297238

Description

Pinostrobin is a neuroprotective flavonoid shown to mitigate Aβ(25-35)-induced toxicity in PC12 cells. Its mechanism involves reducing oxidative stress, preventing calcium overload, and inhibiting mitochondrial apoptosis. This compound is a valuable research tool for studying neuroprotection in models of Alzheimer's disease and related oxidative stress paradigms.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Protein Biochemistry

Images & Validation

Key Properties

CAS Number480-37-5
MW270.28
Purity99.55%
FormulaC16H14O4
SMILESCOc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccccc1
TargetBeta Amyloid,Interleukin,Serine Protease,TNF,Serine/threonin kinase,IL Receptor,HSV,Apoptosis
SolubilityDMSO:60 mg/mL (221.99 mM)

Bioactivity

In Vitro
Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom

Storage & Handling

Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Beta Amyloid, cholesterol, BetaAmyloid, anti-cancer,neuroprotective, anti-inflammatory, anti-oxidant, bAmyloid, b Amyloid, PCSK9, inhibit, foxO3a, Inhibitor, IL Receptor, ILReceptor, βAmyloid, β Amyloid, Pinostrobin, TNF-α, Ser/Thr Protease, Serine endopeptidases, Serine kinase, Serine proteases, Threonine proteases, threoninkinase, threonin kinase, Serinekinase

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Quality Guarantee

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Key Properties

No computed properties available.

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Pinostrobin (orb1297238)

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Available Sizes

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1 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 180.00
5 mg
$ 190.00
10 mg
$ 280.00
DispatchUsually dispatched within 3-5 working days
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