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Pirodavir

SKU: orb1307540

Description

Pirodavir (R77975) is a broad-spectrum anti-picornaviral agent that functions as a potent capsid-binding inhibitor, specifically targeting human rhinovirus (HRV). It serves as a key research tool for studying picornavirus replication and has demonstrated antiviral activity in both in vitro cell culture assays and in vivo animal models of enterovirus infection.
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Research Area

Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

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Pirodavir

Key Properties

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CAS Number124436-59-5
MW369.46
Purity99.78% (May vary between batches)
FormulaC21H27N3O3
SMILESCCOC(=O)c1ccc(OCCC2CCN(CC2)c2ccc(C)nn2)cc1
TargetVirus Protease,Antiviral
SolubilityDMSO:11 mg/mL (29.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.71 mM)

Bioactivity

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In Vitro
Pirodavir is a potent, broad-spectrum picornavirus inhibitor with significant efficacy against various human rhinoviruses (HRV) and enteroviruses. It inhibits 80 out of 100 HRV strains at 64 ng/mL and shows comparable activity against 16 enteroviruses with an IC80 averaging 1,300 ng/mL. Additionally, Pirodavir suppresses enterovirus 71 replication with an IC50 of 5,420 nM and an IC90 exceeding 13,350 nM. It inhibits 56 rhinovirus laboratory strains and three clinical isolates, achieving a 59% inhibition rate for tested serotypes and isolates at IC50 values below 100 nM. Cytotoxicity studies show Pirodavir concentrations of 16 and 4 μg/mL reduce cell growth by 66% and 28%, respectively, and higher tolerance in confluent HeLa cells at 33°C, where the 50% cytotoxic concentration exceeds 50 μg/mL, compared to 7 μg/mL for logarithmic cell growth at 37°C. These findings underscore Pirodavir's efficacy as a selective picornavirus inhibitor with minimal cytotoxic effects under specific assay conditions.
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Cell Research
Pirodavir (R 77975) is dissolved in DMSO (10 mg/mL) and stored, and then diluted in growth medium before use. HeLa cells are seeded at a concentration of approximately 180,000 cells per dish in six-well plates containing 4 mL of growth medium. Growth medium consist of Eagle's basal medium, supplemented with 5% fetal calf serum, 2% sodium bicarbonate, and 1% glutamine. After 24 h of incubation at 37°C in a humidified CO2 atmosphere, the growth medium is removed and replaced by the test solutions (fresh growth medium with or without various concentrations of the antiviral compounds). To assess the cytotoxicity of the antiviral compounds (e.g., Pirodavir), the number of living cells are determined present in triplicate cultures at the time of Pirodavir addition and every 24 h for 3 days. Following trypsinization, the number of viable cells for each drug concentration is counted in triplicate with a Coulter Counter.
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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inhibit, Enterovirus, HRVs, HRV, Inhibitor, HEVs, HEV, Rhinovirus, R 77975, R77975, R-77975, Pirodavir, Virus Protease, VirusProtease

Similar Products

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  • Pirodavir

    Pirodavir [orb1226686]

    >98% (HPLC)

    124436-59-5

    369.46

    C21H27N3O3

    1 g, 100 mg, 500 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
71345 ↗

Key Properties

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No computed properties available.

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Pirodavir (orb1307540)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 150.00
25 mg
$ 280.00
50 mg
$ 420.00
100 mg
$ 570.00
200 mg
$ 760.00
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