Pramipexole 2HCl Monohydrate

SKU: orb1222570

Description

Pramipexole Dihydrochloride is a D2/3 agonist. It acts by reducing mitochondrial ROS production and inhibiting the activation of apoptotic pathways.(In Vitro):Pramipexole dihydrochloride hydrate shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM.Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size.Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures.(In Vivo):Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals.Pramipexole dihydrochloride hydrate improves neurological recovery.Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	191217-81-9
MW	302.26
Purity	>98% (HPLC)
Formula	C₁₀H₁₇N₃S·2HCl·H₂O
SMILES	O.Cl.CCCN[C@H]1CCc2c(C1)sc(N)n2.Cl
Target	D2S\|D2L\|D3\|D4
Solubility	In Vitro: H2O : 100 mg/mL (330.84 mM)

Bioactivity

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In Vivo

Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals. Pramipexole dihydrochloride hydrate improves neurological recovery. Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Animal model: Male Wistar rats weighing 250-300 g (16-18 weeks old). Dosage: 0.25 mg/kg, 1 mg/kg. Administration: Intraperitoneal injection. Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.

In Vitro

Pramipexole dihydrochloride hydrate shows a low binding affinity for D1-type receptor, with an IC50 of >50, 000 nM. Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size. Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Pramipexole Dihydrochloride Monohydrate | Pramipexole Dihydrochloride

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Gene Symbol

D2S|D2L|D3|D4

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