Procyanidin A2

SKU: orb1297536

Description

Procyanidin A2 is a bioactive polyphenol with demonstrated antioxidant, anti-inflammatory, and anti-hyperglycemic properties in research. It shows potential in metabolic and liver health studies, evidenced by in vitro activities including hepatoprotection against alcohol-induced injury and promotion of liver cell regeneration in wound healing assays.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	41743-41-3
MW	576.50
Purity	99.85%
Formula	C₃₀H₂₄O₁₂
SMILES	[H][C@@]1(O)[C@]2([H])c3c(O)cc(O)cc3O[C@]1(Oc1cc(O)c3C[C@@H](O)[C@H](Oc3c21)c1ccc(O)c(O)c1)c1ccc(O)c(O)c1
Target	IL Receptor,transporter,Antibacterial,TNF
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.00 mg/mL (6.94 mM);DMSO:100.00 mg/mL (173.46 mM)

Bioactivity

−

In Vitro

Here we evaluated Procyanidin A2 as a means of modulating CCL26 production and investigated interactions with the known inflammation modulator, Interferon γ (IFNγ). We used the human lung epithelial cell line A549 and optimized the conditions for inducing CCL26. Cells were exposed to a range of Procyanidin A2 or IFNγ concentrations for varied lengths of time prior to an inflammatory insult of interleukin-4 (IL-4) for 24 h. An enzyme-linked immunosorbent assay was used to measure CCL26 production. Exposing cells to 5 μM Procyanidin A2 (prior to IL-4) reduced CCL26 production by 35% compared with control. Greatest inhibition by Procyanidin A2 was seen with a 2 h exposure prior to IL-4, whereas IFNγ inhibition was greatest at 24 h. Concomitant incubation of Procyanidin A2 and IFNγ did not extend the inhibitory efficacy of Procyanidin A2

Storage & Handling

−

Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Bacterial, Inhibitor, IL Receptor, GLUT, ILReceptor, inhibit, Procyanidin A-2, Procyanidin A2, Procyanidin A 2, TNF-α

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

124025 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Procyanidin A2 (orb1297536)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

CAS Number:	86631-38-1
MW:	1155.02
Formula:	C₆₀H₅₀O₂₄

Purity:	>98% (HPLC)
CAS Number:	41743-41-3
MW:	576.51
Formula:	C₃₀H₂₄O₁₂

Procyanidin A2

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Cinnamtannin A2 (Standard) [orb3140547]

Procyanidin A2 (Standard) [orb3140919]

Procyanidin A2 [orb1218047]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Procyanidin A2 (orb1297536)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors