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Protosappanin B

SKU: orb1222926

Description

Protosappanin B significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.

Images & Validation

Key Properties

CAS Number102036-29-3
MW304.29
Purity>98% (HPLC)
FormulaC16H16O6
SMILESC1C2=CC(=C(C=C2C3=C(C=C(C=C3)O)OCC1(CO)O)O)O
TargetOthers
SolubilityIn Vitro: DMSO : 50 mg/mL (164.32 mM)

Bioactivity

In Vitro
Protosappanin B (12.5, 25, 50, 100, 200 μg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 μg/mL, 26.73 μg/mL, and 76.53 μg/mL for SW-480, HCT-116, and BTT cells, respectively. Cell Viability Assay Cell line: CT-116, SW-480, and BTT Cells. Concentration: 12.5, 25, 50, 100, 200 μg/mL Incubation time: 48 hours. Result: Dose-dependently inhibited tumor cells after 48 hours of treatment.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(-)-Protosappanin B

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Protosappanin B (orb1222926)

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5 mg
$ 120.00
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25 mg
$ 280.00