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PS210

SKU: orb1307839

Description

PS210 is a potent and selective PDK1 activator (Kd: 3 μM) that binds its PIF pocket without affecting kinases like S6K or Akt. Its prodrug, PS423, acts as a substrate-selective cellular PDK1 inhibitor, blocking S6K phosphorylation. These compounds are valuable research tools for studying PDK1-dependent signaling pathways in cancer and metabolic disease models.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1221962-86-2
MW380.31
Purity99.78% (May vary between batches)
FormulaC19H15F3O5
SMILESOC(=O)C(C(CC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(O)=O
TargetPDK
SolubilityDMSO:60 mg/mL (157.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

Target IC50
PDK1:(kd)3 μM
In Vitro
PS210 stabilized the residue Arg131 when PS210 causes stabilization of PDK1 to the temperature gradient, located opposite to the helix a-B at the other extreme of the helix a-C. So, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

a-B, Arg131, inhibit, Lys76, Inhibitor, helix, Thr148, pocket, PDK-1, PDK1, PIF-binding, PIFtide, PS 210, PS210, PS-210, PS423, S6K

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Key Properties

No computed properties available.

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Protocol Information

PS210 (orb1307839)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 150.00
25 mg
$ 250.00
50 mg
$ 410.00
100 mg
$ 590.00
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