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Psoralidin

SKU: orb1222586

Description

Psoralidin is a metabolic product from the seed of psoraleacorylifolia, possessing anti-inflammatory and immunomodulatory effects. Psoralidin inhibits lipopolysaccharide induced bone resorption by suppressing the inflammatory cytokines: TNF-α and IL-6 expression, as well as the ratio of RNAKL : OPG.

Images & Validation

Key Properties

CAS Number18642-23-4
MW336.34
Purity>98% (HPLC)
FormulaC20H16O5
SMILESCC(=CCc1c(cc2c(c1)c1c(c3c(o1)cc(cc3)O)c(=O)o2)O)C
TargetAkt| Phosphatidylinositol 3-kinase
SolubilityIn Vitro: DMSO : 50 mg/mL (148.66 mM)

Bioactivity

In Vivo
Animal model: BALB/c mice. Dosage: 5 mg/kg. Administration: Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy). Result: Anti-inflammatory effect in IR-irradiated mice.
In Vitro
Cell Viability Assay Cell line: ALDH- cells, ALDH+ cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A). Concentration: 10, 15, 50, and 25 μM. Incubation time: 24 hours. Result: IC50s of 18 to 21 μM for ALDH- cells, ALDH+ cells, commercial BCSCs. Apoptosis Analysis Cell line: ALDH- cells, ALDH+ cells, and commercial BCSCs. Concentration: 20 and 30 μM. Incubation time: 24 hours. Result: No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH- cells, ALDH+ cells, and commercial BCSCs, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Psoralidin

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  • Psoralidin (Standard) [orb3139516]

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Psoralidin (orb1222586)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 110.00
10 mg
$ 160.00
25 mg
$ 260.00
50 mg
$ 370.00
100 mg
$ 530.00
500 mg
$ 1,160.00