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Q-VD-OPH

SKU: orb1310761
FeaturedFeatured Product

Description

Q-VD-OPH

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

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Q-VD-OPH

Key Properties

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CAS Number1135695-98-5
MW513.5
Purity98.95%
FormulaC26H25F2N3O6
SMILESCC(C)[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N[C@@H](CC(O)=O)C(=O)COc1c(F)cccc1F
TargetHIV Protease,Caspase
SolubilityEthanol:100 mg/mL (194.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.74 mM);DMSO:260 mg/mL (506.33 mM)

Bioactivity

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Target IC50
Caspase-10:25-400 nM|Caspase-12:25-400 nM|Caspase-9:25 nM-400 nM|Caspase-3:25 nM-400 nM|Caspase-1:25 nM-400 nM|Caspase-8:25 nM-400 nM|Caspase-7:48 nM
In Vivo
METHODS: To study the effects of Q-VD-OPH on apoptosis, immune response, and virus replication, SIVmac251 virus was administered intravenously to Chinese macaques to mimic HIV infection, and Q-VD-OPH (20 mg/kg) was administered intravenously to Chinese macaques on days 5, 7, 9, 11, and 14. RESULTS: Q-VD-OPH significantly reduced the level of apoptosis of T cells in peripheral lymph nodes. The number of TUNEL+ cells was significantly lower in the Q-VD-OPh treated group than in the untreated group. Q-VD-OPH treatment significantly increased CD4+ T cell count and CD4/CD8 ratio and decreased viral replication. METHODS: To study the protective effect of Q-VD-OPH on ischemic acute renal failure (ARF), Q-VD-OPH (120 mg/kg) was intraperitoneally injected into mice. RESULTS: Q-VD-OPH inhibited the expression of caspase-1 and IL-18 and neutrophil infiltration in ischemic ARF mice. METHODS: To study the protective effect of Q-VD-OPH on myocardial injury, Q-VD-OPH (50 mg/kg) was intraperitoneally injected into virus-infected mice on days 3 to 6. RESULTS: Q-VD-OPH protected against virus-induced myocardial injury by inhibiting caspase activity. METHODS: To study the therapeutic effect of Q-VD-OPH on AD, TgCRND8 mice were intraperitoneally injected with Q-VD-OPH (10 mg/kg) three times a week for three months. RESULTS: Q-VD-OPH inhibited caspase-7 activation and the pathological changes associated with tau protein, including caspase cleavage.
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In Vitro
METHODS: The apoptosis of cardiomyocytes treated with Q-VD-OPH was detected by Flow Cytometry RESULTS: Q-VD-OPH could protect cardiomyocytes from virus-induced apoptosis.
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Cell Research
Caspase inhibitors are added at the indicated concentrations 30 minutes prior to the addition of apoptotic stimuli. Viability and cell number are determined by trypan blue exclusion from three random fields of greater than 200 cells/field. All experiments are performed a minimum of three times.(Only for Reference)
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Storage & Handling

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Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Q VD OPH, Quinoline-Val-Asp-Difluorophenoxymethylketone, QVDOPH, Q-VD-OPH, QVD-OPH, Human immunodeficiency virus, Inhibitor, HIV, HIV Protease, HIVProtease, inhibit, Caspase-3, Caspase-1, Caspase, Caspase-8, Caspase-9

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID
24794416 ↗

Key Properties

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No computed properties available.

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Q-VD-OPH (orb1310761)

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% DMSO +
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% Tween 80 +
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1 mg
$ 170.00
5 mg
$ 320.00
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