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QC-182

SKU: orb3133602

Description

QC-182 is a potent p300/CBP PROTAC degrader. It reduces p300 protein levels in SK-HEP-1 cells with a DC50 of 93 nM. QC-182 effectively inhibits cell growth in SK-HEP-1 and JHH7 cell lines, with IC50 values of 0.733 μM and 0.477 μM, respectively. QC-182 is applicable for hepatocellular carcinoma (HCC) research.

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Key Properties

CAS Number3032646-96-8
MW816.85
FormulaC44H42F2N8O6
SMILESO=C1N([C@H](C=2N(C=3C(N2)=CC(=CC3)C=4C(C)=NOC4C)C5CCN(CC5)C6CN(C6)C=7C=C8C(=CC7)C(=O)N(C8=O)C9C(=O)NC(=O)CC9)CCC1)C%10=CC(F)=C(F)C=C%10
TargetHistone Acetyltransferase,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

QC-182 (orb3133602)

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