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QL-X-138

SKU: orb1691670

Description

QL-X-138 is a dual kinase inhibitor that covalently targets BTK and non-covalently inhibits MNK, with respective IC₅₀ values of 9.4 nM and 26-107.4 nM. It is used in B-cell malignancy research and also exhibits anti-dengue virus 2 activity with an IC₅₀ of 3.5 µM.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Images & Validation

Key Properties

CAS Number1469988-63-3
MW421.45
Purity99.50%
FormulaC25H19N5O2
SMILESO=C1N(C2=C3C(=NC=C2C=C1)C=CC(=C3)C=4C=NNC4)C5=CC(NC(C=C)=O)=C(C)C=C5
TargetBTK,Anti-infection,MNK,Virus Protease

Bioactivity

In Vitro
QL-X-138 (0.5-5 μM; 24-72 h) arrests the progression of Ramos, OCI-AML-3, U937, and U2932 cells cycle in a dose-dependent manner. QL-X-138 (0.5-5 μM; 8-72 h) induces apoptosis of Ramos, OCI-AML-3, U937 and U2932 cells in a time- and dose-dependent manner. QL-X-138 (3-10000 nM; 4 h) blocks BTK- and MNK-mediated signaling in lymphoma and leukemia cells. QL-X-138 (72 h) demonstrates anti-proliferative activity against lymphoma and leukemia cell lines, with GI50 values of 0.31, 1.2, 0.49, 1.4, 0.4, 0.23, 0.95, 1.2, 1.4, 0.23, 1.3, 0.93, 1, and 2.4 μM for TMD8, U2932, Ramos, OCI-AML3, SKM-1, NOMO-1, NB4, HEL, U937, NALM6, MEC-1, MEC-2, Hs 505.T, and REC-1 cells, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Virus Protease, VirusProtease, QL X 138, QL-X 138, QLX138, QL-X138, QL-X-138, MNK, Dengue Fever virus, BTK

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Key Properties

No computed properties available.

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Protocol Information

QL-X-138 (orb1691670)

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1 mg
$ 240.00
5 mg
$ 620.00
10 mg
$ 760.00
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